Inflammatory myofibroblastic tumor breast. Although CAFs are a major component of the breast cancer stroma, molecular and phenotypic heterogeneity of CAFs in breast Nov 5, 2019 · Inflammatory myofibroblastic tumors are rare mesenchymal myofibroblastic lesions of intermediate malignant potential with tendency for local recurrence and rare metastases usually seen within the The differential diagnosis includes inflammatory myofibroblastic tumor (IMT), atypical cellular myofibroma, leiomyosarcoma and nodular fasciitis among others. IMT has a predilection for the lung, abdomen, pelvis, and retroperitoneum, however, can affect any part of the body. Feb 12, 2015 · Inflammatory myofibroblastic tumors (IMTs) of the breast represent extremely rare lesions. X-ray or computer tomography (CT) scan were performed on 11 cases. Inflammatory myofibroblastic tumor of soft tissue is a histologically distinctive myofibroblastic spindle cell neoplasm of borderline malignancy, classically featuring an intermixture of plasma cells and lymphocytes. We report on a case of a primary breast IMT in a postmenopausal female patient treated success … Radiological findings for inflammatory myofibroblastic breast tumors also tend to be similar to primary breast cancer tumors, so a biopsy and histological evaluation is always justified. It is an ultra-rare tumor, the optimal management of which remains to be defined. IMT represents the neoplastic subset of the family of inflammatory pseudotumors, an umbrella term for spindle cell proliferations of unc … Sep 3, 2023 · Few reports of inflammatory myofibroblastic tumor (IMT) of the breast have been published worldwide. Jul 1, 2005 · No lesions were positive for anaplastic lymphoma kinase-1, desmin, S-100, CD34, CD21, or CD35. However, only few systematic clinical and/or radiological studies have been conducted. Dec 1, 2022 · Inflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer Aug 12, 2022 · Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. 001 Corpus ID: 43372858; Inflammatory myofibroblastic tumor of the breast. In each case, a diagnosis of inflammatory myofibroblastic tumor was made (aka, inflammatory pseudotumor). So far, the pathogenesis of IMT is still unclear, and it was initially thought to be related to trauma, infection, surgery, and other stimuli, which finally activated myofibroblasts with proliferative potential to Mar 1, 2022 · Inflammatory pseudotumor (IPT) was first described in 1903 as a benign, non-infective, local lesion of the orbital region [1]. }, author={Elham Khanafshar and Julia Phillipson and David P. It Background: Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. 2005. (B) Pulmonary inflammatory myofibroblastic tumor exhibiting distinct collagenous stroma with scattered plasma cell infiltrate. The pathologists facing with a bland-looking spindle cell lesion of the breast should keep in mind a wide variety of benign and malignant lesions, including reactive spindle cell nodule, nodular fasciitis, IgG4-related sclerosing mastitis, myofibroblastoma, solitary fibrous tumor, desmoid-type Nov 1, 2003 · Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. However, a detailed analysis of the development of terminology suggests that the term "inflammatory myofibroblastic tumors" should be used to refer to a neoplastic lesion. Jul 26, 2018 · The diagnosis of IMT/IP arising in the breast is challenging, especially on a core needle biopsy. MRI was IMT is a rare entity with intermediate clinical behavior and knowledge of this entity and its recurrence and metastatic potential is of paramount significance to guide appropriate treatment and follow-up. LGMS of the breast are tumors of stromal origin and are etiologically more likely to have hematologic We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. Li-Fraumeni syndrome: Patients with Li-Fraumeni syndrome (usually resulting from heritable cancer-associated changes of the TP53 tumor suppressor gene) have an increased risk of developing soft tissue tumors (mostly NRSTS), bone sarcomas, breast cancer, brain tumors, and acute leukemia. 2015 Jun;18(2):200-205. IMT demonstrates a prominent inflammatory cell infiltrate, which is typically absent in LGMS and harbors fusions of ALK or other kinases 73. inflammatory myofibroblastic tumors of the breast with metastasis: radiographic and histopathologic predictive factors. Nov 18, 2020 · Cytomorphological analysis of an inflammatory myofibroblastic tumor. The name of the disease was introduced 2 years later, and the tumors were described as characterized by proliferation of fibroblasts and myofibroblasts, accompanied by chronic inflammatory infiltration by lymphocytes, plasma cells, eosinophils and histiocytes [2]. These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), intermediate–locally aggressive (eg, lipofibromatosis Inflammatory myofibroblastic tumor was initially regarded as a benign tumor that most often developed in the lung and less commonly in almost any organ system or tissue. Gonzalez, M. 2 Previously known by various names such as inflammatory pseudotumor, plasma cell granuloma, histiocytoma, and fibroxanthoma Feb 15, 2022 · Inflammatory myofibroblastic tumors (IMTs) of the breast originate from mesenchymal tissue and are mainly composed of myofibroblast and multiple inflammatory cells (lymphocyte, plasmacyte and eosinophil). @article{Khanafshar2005InflammatoryMT, title={Inflammatory myofibroblastic tumor of the breast. Here, we present the clinical imaging results and report the significance of sonographic findings of breast IMT along with a review of the literature. Case presentation A 52-year-old woman underwent a medical examination, and a left breast mass was eoperational differential diagnosis based on imaging manifestations. 1016/J. . Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential with a predilection for the lung and abdominopelvic region. We report these patients to emphasize the diagnostic features of inflammatory myofibroblastic tumor of the breast and discuss how they can be distinguished from other spindle-cell breast lesions with which they can be confused, especially spindle-cell carcinoma. IMT is typi … Apr 24, 2023 · Mesenchymal breast tumors are a rare and diverse group of tumors that present some of the most challenging cases for multidisciplinary breast cancer teams. 2015. Breast IMTs are easily misdiagnosed as other types of malignant lesions, and therefore there is a significant unmet need for a better preoperational differential diagnosis based on imaging Mar 3, 2023 · Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. Its pathogenesis and biological behavior have not yet been May 12, 2024 · Moreover, CK expression is commonly seen in other myofibroblastic proliferations, like the inflammatory myofibroblastic tumor . Because of the lack of typical imaging and clinical characteristics of IMT, it is easy to misdiagnose before operation. doi: 10. IMT is rare and its true incidence and prevalence remains unclear ( 1 ). The main concern is to arrive at an accurate diagnosis and not over treat the lesion with grossly unnecessary procedures such as mastectomy , with or without Jun 1, 2021 · Inflammatory myofibroblastic tumor (IMT) is a rare tumor with low-grade malignant risk mainly occurring in soft tissues and lungs, and it is extremely rare in the breast. 1159/000354250 Published online: August 19, 2013 Inflammatory Myofibroblastic Tumor of the Breast Coexisting with Breast Cancer: A Case Report Jian Lia* Wen Yuna* Jianwei Qina Jianhua Zhaob Xuemin Liuc Jianzhong Wua Minghua Jia Jinhai Tanga a Cancer Hospital of Jiangsu Province, Clinical Laboratory Center of Jiangsu The terms "inflammatory myofibroblastic tumors" and "inflammatory pseudotumors" are interchangeably used by many scientists. The mammograms of breast LGMS are generally irregular shapes and high density, with a lack of encapsulation . Modified radical mastectomy was performed, followed by Sep 1, 2023 · Background Few reports of inflammatory myofibroblastic tumor (IMT) of the breast have been published worldwide. In the present study, we present a case of IMT in a 56-year-old female patient who was admitted to our hospital due to a mass found in her right breast. Furthermore, primary anaplastic lymphoma kinase (ALK)-positive IMT of the breast is extremely rare. May 31, 2021 · Here, we report a case of inflammatory myofibroblastic tumor in the breast with the imaging findings of mammography, magnetic resonance imaging (MRI), and pathologic findings to improve the understanding of the disease. Jul 27, 2022 · An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. IMTs are one of the most frequent lung tumors in children, accounting for between 16% and 38% of cases in various series. Inflammatory myofibroblastic tumor, or IMT, forms in tissues called mucosal surfaces and mesentery. To date, only six patients with ALK-positive IMT have been reported in the literature. Feb 6, 2022 · Background: Inflammatory myofibroblastic tumors (IMTs) are defined as tumors composed of differentiated myofibroblastic spindle cells, usually accompanied by numerous plasma cells and lymphocytes, and classified as intermediate (occasionally metastatic) by the World Health Organization. Methods This study recruited 14 cases (8 males and 6 females) of LGMS. Patient concerns: The patient, a 43-year-old female, reported the presence of a palpable lump within her left breast. We retrospectively searched for records Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast. Epub 2022 Aug 12 doi: 10. Case Report · Kasuistik Breast Care Breast Care 2013;8:290–292 DOI: 10. The latter recurrence was managed successfully with a second excision. Magnification Jun 1, 2021 · Inflammatory myofibroblastic tumor of the breast is an extremely rare entity that can recur, with a recurrence rate of 25% . Oct 1, 2012 · Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. Learn more about treatment and the prognosis for IMT. 1155/2022/1863123. The World Health Organization has classified IMTs as tumors of intermediate biological potential because they have a tendency to recur locally and are associated with a slight risk of Mar 3, 2021 · Epithelioid inflammatory myofibroblastic sarcoma: similar, except cells are more epithelioid, with large nucleoli Microscopic (histologic) images Contributed by Raul S. Herein, we present a non-systematic review that focuses on progress, or lack thereof, in the Rationale: Inflammatory myofibroblastic tumors (IMTs), particularly breast IMTs, are rare neoplastic lesions typically associated with a favorable prognosis. ANNDIAGPATH. INTRODUCTION. Inflammatory myofibroblastic tumors (IMTs) of the breast represent extremely rare lesions. [8,9] Aug 10, 2018 · Inflammatory myofibroblastic tumors (IMTs), particularly breast IMTs, are rare neoplastic lesions typically associated with a favorable prognosis. Dec 1, 2019 · In addition, we think that potential diagnostic errors are likely to occur because the pathologist: i) is faced with an unfamiliar lesion (myofibroblastoma; low-grade myofibroblastic sarcoma; low-grade fibromatosis-like spindle cell carcinoma); ii) pathologist is not familiar with soft tissue pathology (nodular fasciitis; desmoid-type Oct 1, 2017 · Inflammatory myofibroblastic tumor (IMT) of the breast, first reported at 1988 (1), is now considered as a true low-grade neoplasm and mixture of spindle cells and chronic inflammatory cells, such May 21, 2020 · Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and molecules secreted by CAFs play an important role in tumor progression and metastasis. Liu S, Yuan R, Jin Y, He C, Zheng X, Zhan Y Breast J 2022;2022:1863123. Jun 26, 2015 · Inflammatory myofibroblastic tumors (IMTs) of the breast are rare tumors of unknown etiology that may be confused clinically and radiologically with malignancy . A 16- … Inflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer clinico-radiologically. Feb 2, 2022 · Core Tip: We believe that our study makes a significant contribution to the literature because inflammatory myofibroblastic tumors (IMTs) of the breast are rare and unique; however, whether they are reactive or neoplastic in nature remains unelucidated. This case presented the opportunity to review studies regarding cases of inflammatory Jun 1, 2005 · We report 3 additional patients to emphasize the diagnostic features of inflammatory myofibroblastic tumor of the breast and to discuss how they can be distinguished from other spindle-cell breast lesions with which they can be confused, especially spindle-cell carcinoma—a clearly malignant tumor with marked different prognosis and therapy. T … Jul 8, 2021 · Inflammatory myofibroblastic tumor (IMT) is a kind of mesenchymal tumor characterized with proliferation of myofibroblast spindle cells and prominent infiltration of plasmocytes and/or lymphocytes. An ultrasound examination revealed an irregular hypoechoic mass with unclear Jun 1, 2005 · The differential diagnosis of inflammatory myofibroblastic tumor of the breast includes spindle-cell (metaplastic) breast carcinoma, fibromyxoid sarcoma, malignant fibrous histiocytoma, inflammatory fibrosarcoma, extramedullary plasmacytoma, and various benign lesions, such as fibromatosis, nodular fasciitis, biopsy repair reaction, and Jun 3, 2023 · Myofibroblastoma is a benign rare spindle-cell breast tumor, which is rare and reported to have a slight male predisposition. Aug 1, 2021 · Other tumors are much more common at extramammary soft tissue sites, such as nodular fasciitis, dermatofibrosarcoma protuberans, inflammatory myofibroblastic tumor, low-grade fibromyxoid sarcoma, myxofibrosarcoma, and low-grade myofibroblastic sarcoma. Here, we report the imaging findings of a breast IMT and compare our findings with previously published features of breast IMTs. We now report a case of a 37-year-old woman presenting with a mass in her left breast. Meanwhile, imaging findings of the tumor often present with non-specific features that lead to misdiagnosis and delayed treatment … Oct 1, 2016 · Inflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer clinico-radiologically. CAFs coexist as heterogeneous populations with potentially different biological functions. A 16-year-old girl with a history of subarachnoidal hemorrhage was admitted to our hospital due to Jun 1, 2005 · DOI: 10. Aug 19, 2013 · The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature. IMT can occur in adults at several anatomic sites, including the breast. Oct 27, 2019 · Inflammatory myofibroblastic tumor (IMT) is currently classified by WHO as a soft tissue tumor composed of spindly myofibroblasts admixed with inflammatory cells such as plasma cells, lymphocytes, and eosinophils (Coffin and Fletcher 2013). Inflammatory myofibroblastic tumor of the breast is an extremely rare lesion. Over time, however, IMT cases occurred in which the tumor spread into local tissues, metastasized to distal tissues, recurred after treatment, or consisted of neoplastic cells Inflammatory Myofibroblastic Tumor of Breast is a very rare and mostly benign tumor affecting the breast. Schammel and Lorraine Minobe and Judith Cymerman and Noel Weidner}, journal={Annals of diagnostic pathology}, year={2005}, volume Aug 12, 2022 · Inflammatory myofibroblastic tumor (IMT) is a rare myofibroblastic neoplasm that most frequently occurs in children and young adults. Various benign and malignant conditions are known to occur in the male breast. [1-3] Background: Inflammatory myofibroblastic tumor (IMT) of the breast is a very rare tumor like lesion with only 6 previously reported cases. It was first described in the lung, but its occurrence at various extrapulmonary sites has also been reported. Aug 7, 2024 · Inflammatory myofibroblastic tumors (IMTs) occur throughout the body, but the lungs are the most commonly involved organs. They are composed of fibroblasts and myofibroblasts and are not associated with malignant potential. Previous research has paid much attention to reporting pathological analyses of LGMS. [1] It was first described in 1987, and since then, there have been various pathological, surgical, and radiographical publications in the literature. May 5, 2022 · Myofibroblastomas are rare benign spindle cell tumors that occur within both male and female breasts. IMT is a rare borderline mesenchymal neoplasm that arises most commonly in the lung, peritoneum, and liver. In the present study, we present a case of IMT in a 56 May 2, 2019 · Background Low-grade myofibroblastic sarcoma (LGMS) is a rare type of tumor. A woman aged 38 years with a breast mass was referred to our general surgery clinic. Breast IMTs are easily misdiagnosed as other types of malignant lesions, and therefore there is a significant unmet need for a better preoperational differential diagnosis based on imaging manifestations. Very little is known about the cytology of IMT. They generally affect younger populations, especially females Inflammatory myofibroblastic tumor (IMT) is generally considered as a benign tumor with aggressive behavior (low-grade tumor), which can occur anywhere in the body Oct 12, 2017 · We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. IMT usually starts in the lung, but it can also begin in many other places. (A) Long spindle cells contained small nuclei with vesicular chromatin and scattered plasma cells and lymphocytes. IMTs are mostly found in children and young adults but can occur at any age. Given its rarity, myofibroblastoma poses a challenge to pathologists when differentiating between benign and malignant Jul 11, 2016 · Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. 02. The clinical and pathological features of IMT in adult patients are not well understood. 1 Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. Here, we report a unique case of an IMT coexisting with breast cancer. Feb 12, 2015 · The World Health Organization (WHO) classifies inflammatory myofibroblastic tumors (IMTs) as distinct borderline lesions, while the physical history of these lesions can variably range from reactive to truly neoplastic . Due to the scarcity of reports, their natural history, recurrence, and metastatic potential remain poorly defined. 4048/jbc. As a result of overlapping morphologies and a lack of large-scale studies on these tumors, practices are often heterogeneous and slow to evolve. J Breast Cancer. BACKGROUND Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. The tumor is composed of spindle-shaped myofibroblasts with fascicles or storiform patterns and sometimes within loose myxoid stroma. D. Aug 12, 2022 · Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. Inflammatory myofibroblastic tumor (Pathol Res Pract 2023;242:154335) Interdigitating dendritic cell sarcoma (Am J Surg Pathol 2002;26:530) Leiomyoma (usually) and vascular leiomyoma (Am J Surg Pathol 2001;25:1355, J Clin Pathol 2002;55:395) Leiomyosarcoma (usually) (Arch Pathol Lab Med 2017;141:1072) Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. Magnification, ×400. zrpwkw jfdxb vrqcrl syyfk rejstj ljpgg akn lej sley terekuc